GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs1552244 | 1 | rs6764068 | chr3:10153842 | C3orf10 | chr3:10157333-10168873:+ | -0.21 | -4.49 | 8.8E-6 | Alzheimer's disease |
| THCA | cis | rs1552244 | 1 | rs6764068 | chr3:10153842 | VHL | chr3:10183319-10193744:+ | -0.19 | -4.42 | 1.21E-5 | Alzheimer's disease |
| THCA | cis | rs1552244 | 1 | rs6764168 | chr3:10123805 | C3orf10 | chr3:10157333-10168873:+ | -0.21 | -4.32 | 1.86E-5 | Alzheimer's disease |
| THCA | cis | rs1552244 | 1 | rs6764168 | chr3:10123805 | VHL | chr3:10183319-10193744:+ | -0.19 | -4.37 | 1.53E-5 | Alzheimer's disease |
| THCA | cis | rs6764184 | 1 | rs6764184 | chr3:58006266 | PDHB | chr3:58413355-58419565:- | -0.17 | -3.8 | 0.000166 | Optic cup area |
| THCA | cis | rs13191362 | 1 | rs67646369 | chr6:163003233 | PACRG | chr6:163148164-163736523:+ | 0.46 | 7.08 | 5.13E-12 | Body mass index |
| THCA | cis | rs73201462 | 1 | rs6765233 | chr3:128002850 | EEFSEC | chr3:127872313-128127488:+ | 0.26 | 4.53 | 7.38E-6 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs237743 | 1 | rs67652499 | chr20:47926691 | DDX27 | chr20:47835832-47860612:+ | 0.27 | 4.95 | 1.02E-6 | Height |
| THCA | cis | rs9790314 | 1 | rs6765269 | chr3:160948542 | NMD3 | chr3:160939099-160971319:+ | -0.11 | -3.74 | 0.000209 | Morning vs. evening chronotype |
| THCA | cis | rs12304921 | 1 | rs67654320 | chr12:51356459 | SLC11A2 | chr12:51373319-51422058:- | -0.24 | -4.74 | 2.88E-6 | Type 2 diabetes |
| THCA | cis | rs12304921 | 1 | rs67654320 | chr12:51356459 | TFCP2 | chr12:51488608-51566917:- | -0.2 | -4.29 | 2.15E-5 | Type 2 diabetes |
| THCA | cis | rs10935120 | 1 | rs6765505 | chr3:134208132 | ANAPC13 | chr3:134196547-134204865:- | 0.39 | 12.57 | 1.72E-31 | Height |
| THCA | cis | rs10935120 | 1 | rs6765505 | chr3:134208132 | CEP63 | chr3:134204575-134293852:+ | 0.29 | 6.4 | 3.83E-10 | Height |
| THCA | cis | rs9815925 | 1 | rs6766554 | chr3:184728846 | C3orf70 | chr3:184795840-184870802:- | -0.23 | -4.62 | 4.96E-6 | Heschl's gyrus morphology |
| THCA | cis | rs10935120 | 1 | rs6766818 | chr3:134226159 | ANAPC13 | chr3:134196547-134204865:- | 0.4 | 12.84 | 1.2E-32 | Height |